von Schmiesing Alexa, Schmidt Stefan A, Kratzer Wolfgang, Mason Richard A, Imhof Armin, Steinbach Gerald, Akinli Atilla S, Haenle Mark M
Universitätsklinikum Ulm, Zentrale Einrichtung für Klinische Chemie, Albert-Einstein-Allee 23, 89070 Ulm, Germany.
Clin Lab. 2009;55(5-6):193-9.
Aim of the study was to determine reference values for the soluble Transferrin Receptor (sTfR) in a cross sectional population sample.
For the determination of reference values, using a standard calibrated fluorescence-immunoassay, the samples (990 females; 1060 males; 13 - 65 years old) were divided into five groups according to age and sex. Soluble transferrin receptor and ferritin were measured by a fluorescence-immunoassay with AIA-21 (TOSOH BIOSCIENCE, Tessenderlo, Belgium). The sTfR/logFer-Index was calculated by dividing the sTfR by the logarithm of ferritin, the logsTfR/Fer-Index by dividing the logarithm of sTfR by ferritin.
Mean sTfR concentration was 1.75 +/- 0.39 mg/l in group I (13-17 years), 1.65 +/- 0.34 mg/l in group II (18-30 years), 1.60 +/- 0.39 mg/l in group III (31-40 years), 1.54 +/- 0.39 mg/l in group IV (41-50 years), and 1.59 +/- 0.34 mg/l in group V (51-65 years), respectively. A gender-specific difference between the groups was observed: sTfR concentrations were lower in group I (p < 0.005) and group II (p = 0.01) for women. The mean sTfR-concentration decreased consecutively in the age group I-IV (13-50 years).
This is the first cross sectional population based study to determine reference values for sTfR-concentrations. Our results demonstrated age- and gender-specific differences.
本研究的目的是确定横断面人群样本中可溶性转铁蛋白受体（sTfR）的参考值。
为了确定参考值，使用标准校准荧光免疫测定法，将样本（990名女性；1060名男性；年龄13 - 65岁）按年龄和性别分为五组。使用AIA - 21（日本东曹生物科学公司，比利时泰森德洛）荧光免疫测定法测量可溶性转铁蛋白受体和铁蛋白。sTfR/铁蛋白对数指数通过将sTfR除以铁蛋白的对数计算得出；sTfR对数/铁蛋白指数通过将sTfR的对数除以铁蛋白计算得出。
第一组（13 - 17岁）的平均sTfR浓度为1.75±0.39mg/l，第二组（18 - 三十岁）为1.65±0.34mg/l，第三组（31 - 40岁）为1.60±0.39mg/l，第四组（41 - 50岁）为1.54±0.39mg/l，第五组（51 - 65岁）为1.59±0.34mg/l。观察到各年龄组之间存在性别差异：女性在第一组（p < 0.005）和第二组（p = 0.01）中的sTfR浓度较低。在I - IV年龄组（13 - 50岁）中，平均sTfR浓度连续下降。
这是第一项基于横断面人群确定sTfR浓度参考值的研究。我们的结果显示了年龄和性别差异。
