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发作性睡病与精神状态——病例报告

Narcolepsy and psychotic states--a case report.

作者信息

Melamed Yuval, Daliahu Yael, Paleacu Diana

机构信息

Lev Hasharon Mental Health Center, Netanya, Israel.

出版信息

Isr J Psychiatry Relat Sci. 2009;46(1):70-3.

PMID:19728575
Abstract

Narcolepsy is characterized by symptoms that include excessive sleepiness during the daytime, cataplexy, hypnagogic hallucinations and sleep paralysis. We present a single unusual case report of a patient who was admitted to a psychiatric facility. A 20-year-old single woman was hospitalized in a general hospital due to involuntary movements in her limbs. Following complaints of continual daily sleepiness and instances of a loss of muscle tone she was referred for sleep assessment. The patient was diagnosed with narcolepsy and cataplexy. Later, due to auditory hallucinations she was referred to a psychiatric hospital. Her reality judgement was poor, with partial insight regarding her illness. The patient was treated with methylphenidate 20 mg/day and antipsychotic medication; risperidone of up to 4 mg/day, and paroxetine 20 mg/day to prevent cataplexy. Following further exacerbation, pharmacotherapy was changed to risperidone 6 mg/day and modafinil 200 mg/day. This treatment led to a significant improvement in her condition. The report presented here suggests that combined treatment with a psycho-stimulant drug, an SSRI in combination with antipsychotic treatment, may be indicated in narcolepsy with cataplexy and vivid psychotic production. Multidisciplinary cooperation of neurologists and psychiatrists enabled this therapy to be administered for the patient's benefit.

摘要

发作性睡病的特征症状包括白天过度嗜睡、猝倒、入睡前幻觉和睡眠瘫痪。我们报告一例罕见的病例,患者入住了一家精神科机构。一名20岁单身女性因四肢不自主运动入住综合医院。在诉说每日持续嗜睡和多次肌肉张力丧失后,她被转介进行睡眠评估。该患者被诊断为发作性睡病和猝倒症。后来,由于出现幻听,她被转至一家精神病医院。她的现实判断力较差,对自己的病情有部分自知力。患者接受了20毫克/天的哌甲酯和抗精神病药物治疗;最高剂量为4毫克/天的利培酮和20毫克/天的帕罗西汀以预防猝倒。病情进一步加重后,药物治疗改为6毫克/天的利培酮和200毫克/天的莫达非尼。这种治疗使她的病情有了显著改善。本文报告表明,对于伴有猝倒和明显精神症状的发作性睡病,使用精神兴奋药物、选择性5-羟色胺再摄取抑制剂(SSRI)联合抗精神病药物的联合治疗可能是有效的。神经科医生和精神科医生的多学科合作使这种治疗能够为患者带来益处。

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The hypocretin system and psychiatric disorders.下丘脑分泌素系统与精神障碍。
Curr Psychiatry Rep. 2014 Feb;16(2):433. doi: 10.1007/s11920-013-0433-9.
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Comorbidity and mortality of narcolepsy: a controlled retro- and prospective national study.嗜睡症的合并症和死亡率:一项对照回顾性和前瞻性全国性研究。
Sleep. 2013 Jun 1;36(6):835-40. doi: 10.5665/sleep.2706.