Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Glostrup Hospital, Copenhagen, Denmark.
Sleep. 2013 Jun 1;36(6):835-40. doi: 10.5665/sleep.2706.
To identify the factual morbidity and mortality of narcolepsy in a controlled design.
National Patient Registry.
All national diagnosed patients (757) with health information at least 3 years prior to and after diagnose of narcolepsy.
Randomly selected four citizens (3,013) matched for age, sex, and socioeconomic status from the Danish Civil Registration System Statistics.
Increased morbidity prior to narcolepsy diagnosis included (odds ratio, 95% confidence interval):- diseases of the endocrine, nutritional, and metabolic systems (2.10, 1.32-3.33); nervous system (5.27, 3.65-7.60); musculoskeletal system (1.59, 1.23-2.05); and other abnormal symptoms and laboratory findings (1.66, 1.25-2.22). After the diagnosis, narcolepsy patients experienced diseases of the endocrine, nutritional, and metabolic (2.31, 1.51-3.54), nervous (9.19, 6.80-12.41), musculoskeletal (1.70, 1.28-2.26), eye (1.67, 1.03-2.71), and respiratory systems (1.84, 1.21-2.81). Specific diagnoses were diabetes (2.4, 1,2-4.7, P < 0.01), obesity (13.4, 3.1-57.6, P < 0.001), sleep apnea (19.2, 7.7-48.3, P < 0.001), other sleep disorders (78.5, 11.8-523.3, P < 0.001), chronic obstructive pulmonary disease (2.8, 1.4-5.8, P < 0.01), lower back pain (2.5, 1.4-4.2, P < 0.001), arthrosis/arthritis (2.5, 1.3-4.8, P < 0.01), observation of neurological diseases (3.5, 1.9-6.5, P < 0.001), observation of other diseases (1.7, 1.2-2.5, P < 0.01), and rehabilitation (5.0, 1.5-16.5, P < 0.005). There was a trend towards greater mortality in narcolepsy (P = 0.07).
Patients with narcolepsy present higher morbidity several years prior to diagnose and even higher thereafter. The mortality rate due to narcolepsy was slightly but not significantly higher.
以对照设计来明确嗜睡症的实际发病率和死亡率。
国家患者注册中心。
所有在丹麦被诊断为患有嗜睡症（757 人）且至少在诊断前和诊断后 3 年内拥有健康信息的患者。
从丹麦民事登记系统统计中随机选择了 4 名（3013 名）年龄、性别和社会经济地位相匹配的公民作为对照组。
在嗜睡症诊断前，发病率增加的疾病包括（比值比，95%置信区间）：-内分泌、营养和代谢系统疾病（2.10，1.32-3.33）；神经系统疾病（5.27，3.65-7.60）；肌肉骨骼系统疾病（1.59，1.23-2.05）；以及其他异常症状和实验室发现（1.66，1.25-2.22）。诊断后，嗜睡症患者出现了内分泌、营养和代谢系统疾病（2.31，1.51-3.54）、神经系统疾病（9.19，6.80-12.41）、肌肉骨骼系统疾病（1.70，1.28-2.26）、眼部疾病（1.67，1.03-2.71）和呼吸系统疾病（1.84，1.21-2.81）。具体诊断包括糖尿病（2.4，1.2-4.7，P < 0.01）、肥胖症（13.4，3.1-57.6，P < 0.001）、睡眠呼吸暂停（19.2，7.7-48.3，P < 0.001）、其他睡眠障碍（78.5，11.8-523.3，P < 0.001）、慢性阻塞性肺疾病（2.8，1.4-5.8，P < 0.01）、下腰痛（2.5，1.4-4.2，P < 0.001）、骨关节炎/关节炎（2.5，1.3-4.8，P < 0.01）、神经系统疾病的观察（3.5，1.9-6.5，P < 0.001）、其他疾病的观察（1.7，1.2-2.5，P < 0.01）和康复（5.0，1.5-16.5，P < 0.005）。嗜睡症患者的死亡率有升高的趋势（P = 0.07）。
嗜睡症患者在诊断前几年就出现了更高的发病率，甚至在诊断后更高。嗜睡症的死亡率虽略有升高，但无统计学意义。
