风疹病毒与人类免疫细胞的相互作用。I. 淋巴细胞亚群的易感性。

Interaction of rubella virus with human immune cells. I. Permissiveness of lymphocyte subpopulations.

作者信息

Barth M W, Oger J, Chantler J K

机构信息

Division of Medical Microbiology, University of British Columbia, Vancouver, Canada.

出版信息

Viral Immunol. 1990 Summer;3(2):119-25. doi: 10.1089/vim.1990.3.119.

DOI:10.1089/vim.1990.3.119

PMID:1972882

Abstract

The ability of rubella virus to infect and replicate in various lymphocyte subpopulations was examined. Purified populations of B-cells, CD4+ T-cells and CD8+ T-cells were found to support high levels of viral replication. In addition, when mixed PBMC were infected in vitro, viral antigen was shown to be expressed on the surfaces of CD4+ and CD8+ T-cells by flow cytometry indicating that RV does not have a selective tropism for a specific type of lymphoreticular cell.

摘要

研究了风疹病毒在各种淋巴细胞亚群中感染和复制的能力。结果发现，纯化的B细胞、CD4 + T细胞和CD8 + T细胞群体能够支持高水平的病毒复制。此外，当体外感染混合的外周血单个核细胞（PBMC）时，通过流式细胞术显示病毒抗原在CD4 +和CD8 + T细胞表面表达，这表明风疹病毒对特定类型的淋巴网状细胞没有选择性嗜性。