Department of Pathology, Soroka University Medical Center, Israel.
Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):206-9. doi: 10.1016/j.ejogrb.2009.08.008. Epub 2009 Sep 2.
To look for an association between the measles virus and endometrial carcinoma, the most frequent cancer of the female genital tract in our area.
Thirty-six of 49 patients with endometrial carcinoma were studied to detect fingerprints of the measles virus. Immunohistochemistry with the avidin-biotin complex method and in situ hybridization were used to demonstrate the association. The clinicopathological correlations were carried out to support a relationship between the virus and the cancer if any was found.
Twenty-six of the 36 cases (72%) of endometrial cancer showed the presence of measles virus antigens in the tumor cells. Sixteen of 21 cases were positive for measles virus RNA by in situ hybridization. Although type I endometrial carcinoma was more positive for viral particles than type II, type II cancer, when allied with the measles virus, was more often associated with the depth of myometrial invasion and with death from tumor.
We demonstrate for the first time a link between endometrial cancer and the presence of viral antigens and RNA of the measles virus, although these findings do not necessarily signify a causal relationship between the cancer and the virus.
寻找麻疹病毒与子宫内膜癌之间的关联，后者是本地区女性生殖道最常见的癌症。
对 49 名子宫内膜癌患者中的 36 名进行了研究，以检测麻疹病毒的指纹。采用亲和素-生物素复合物法和原位杂交法进行免疫组织化学检测，以证明相关性。进行临床病理相关性分析，如果发现病毒与癌症之间存在任何关系，则支持两者之间的关系。
26 例（72%）子宫内膜癌病例的肿瘤细胞中存在麻疹病毒抗原。21 例中有 16 例通过原位杂交检测到麻疹病毒 RNA 呈阳性。尽管 I 型子宫内膜癌比 II 型更易受病毒颗粒影响，但当 II 型癌症与麻疹病毒联合时，更常与肌层浸润深度和肿瘤死亡相关。
我们首次证明子宫内膜癌与麻疹病毒的病毒抗原和 RNA 之间存在关联，但这些发现并不一定表明癌症与病毒之间存在因果关系。
