Biology Department, University of Roma TRE, Viale G. Marconi 446, Rome I-00146, Italy.
Curr Opin Biotechnol. 2009 Aug;20(4):492-7. doi: 10.1016/j.copbio.2009.08.004. Epub 2009 Sep 3.
The term chemical synthetic biology defines that part of the field that, instead of assuming an engineering approach based on genome manipulation, is oriented towards the synthesis of chemical structures alternative to those present in nature. Several different literature projects will be illustrated, including the two of our group. One is concerned with the 'Never Born Proteins' (NBPs), namely polypeptide sequences that are not present in nature, the other is concerned with the notion of 'minimal cells', semi-synthetic compartments (usually liposomes) containing the minimal and sufficient number of components to perform the basic function of a biological cell.
化学合成生物学的定义是该领域的一部分，它不是基于基于基因组操作的工程方法，而是倾向于合成自然界中不存在的化学结构。将举例说明几个不同的文献项目，包括我们小组的两个项目。一个是关于“从未出生的蛋白质”（NBPs），即自然界中不存在的多肽序列，另一个是关于“最小细胞”的概念，半合成隔室（通常是脂质体）包含执行生物细胞基本功能所需的最小和足够数量的组件。
