总结信息。
Re-capping the message.
作者信息
Schoenberg Daniel R, Maquat Lynne E
机构信息
Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Trends Biochem Sci. 2009 Sep;34(9):435-42. doi: 10.1016/j.tibs.2009.05.003. Epub 2009 Sep 2.
Abstract
The 5'-cap structure that typifies all polymerase II-transcribed RNAs plays important roles in pre-mRNA processing and mRNA export, translation and quality control. Removal of the cap is a regulated process that is considered to be the first irreversible step in mRNA decay. An emerging view challenges this idea: mRNAs have been identified in mammalian cells that lack sequences from their 5' ends but nevertheless appear to be modified with a cap or cap-like structure. Furthermore, a cytoplasmic form of capping enzyme was recently identified that, together with a novel kinase, generates capped ends from cleaved RNAs. These and other findings provide evidence for re-capping and its possible functions.
摘要
典型的所有聚合酶II转录RNA的5'-帽结构在mRNA前体加工、mRNA输出、翻译和质量控制中发挥重要作用。帽的去除是一个受调控的过程，被认为是mRNA降解的第一个不可逆步骤。一种新出现的观点对这一想法提出了挑战：在哺乳动物细胞中已鉴定出一些mRNA，它们从5'端缺失了部分序列，但仍似乎被帽或帽状结构修饰。此外，最近鉴定出一种细胞质形式的加帽酶，它与一种新型激酶一起，能从切割后的RNA产生带帽末端。这些以及其他发现为重新加帽及其可能的功能提供了证据。
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