Department of Biology, University of Pennsylvania, School of Arts and Sciences, 433 S. University Ave., Philadelphia, PA 19104, USA.
Plant Cell. 2023 May 29;35(6):1801-1816. doi: 10.1093/plcell/koad044.
Although covalent nucleotide modifications were first identified on the bases of transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), a number of these epitranscriptome marks have also been found to occur on the bases of messenger RNAs (mRNAs). These covalent mRNA features have been demonstrated to have various and significant effects on the processing (e.g. splicing, polyadenylation, etc.) and functionality (e.g. translation, transport, etc.) of these protein-encoding molecules. Here, we focus our attention on the current understanding of the collection of covalent nucleotide modifications known to occur on mRNAs in plants, how they are detected and studied, and the most outstanding future questions of each of these important epitranscriptomic regulatory signals.
尽管最初在转移 RNA（tRNA）和核糖体 RNA（rRNA）的碱基上发现了共价核苷酸修饰，但也发现了许多这些转录后修饰标记存在于信使 RNA（mRNA）的碱基上。这些共价 mRNA 特征已被证明对这些编码蛋白分子的加工（例如剪接、多聚腺苷酸化等）和功能（例如翻译、运输等）具有各种重要影响。在这里，我们关注当前对植物中存在于 mRNA 上的已知共价核苷酸修饰的理解，以及如何检测和研究这些修饰，以及这些重要的转录后调控信号中的每一个最突出的未来问题。
