Poyrazoglu Sukran, Darendeliler Feyza, Bas Firdevs, Bundak Ruveyde, Saka Nurcin, Darcan Sukran, Wit Jan M, Gunoz Hulya
Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Horm Res. 2009;72(3):178-83. doi: 10.1159/000232494. Epub 2009 Sep 1.
It was the aim of this study to evaluate adult height (AH) and different methods used for estimation of target height (TH) in children with idiopathic short stature (ISS).
Eighty-five ISS children (36 female, 49 male) were followed until AH was evaluated retrospectively. TH was calculated according to the following 4 methods: (1) as +/-6.5 cm to the mean parental heights for boys or girls, respectively, (2) as the mean standard deviation score (SDS) of the parents' heights, (3) as the sum of the SDS of the parents' heights divided by 1.61, and (4) as the mean SDS of the parents' heights multiplied by 0.72. ISS was classified as familial short stature (FSS) if the height was within the TH range and as nonfamilial short stature (NFSS) if it was below the TH range.
The number of FSS and NFSS children differed by the method chosen. The mean AH SDS was lower than the TH SDS in FSS in all methods, except in method 3. NFSS children did not attain their TH in either of the methods.
Classification of ISS depends on the method of the TH range chosen. ISS children reach a mean AH SDS lower than the mean TH SDS. Only FSS children classified by method 3 reached a mean AH SDS close to the mean TH SDS.
本研究旨在评估特发性身材矮小（ISS）儿童的成人身高（AH）以及用于估计靶身高（TH）的不同方法。
对85名ISS儿童（36名女性，49名男性）进行随访，直至对AH进行回顾性评估。根据以下4种方法计算TH：（1）男孩或女孩分别为父母平均身高±6.5厘米；（2）为父母身高的平均标准差评分（SDS）；（3）为父母身高的SDS总和除以1.61；（4）为父母身高的平均SDS乘以0.72。如果身高在TH范围内，ISS被分类为家族性身材矮小（FSS），如果低于TH范围，则分类为非家族性身材矮小（NFSS）。
FSS和NFSS儿童的数量因所选方法而异。除方法3外，在所有方法中，FSS儿童的平均AH SDS均低于TH SDS。NFSS儿童在任何一种方法中都未达到其TH。
ISS的分类取决于所选TH范围的方法。ISS儿童的平均AH SDS低于平均TH SDS。只有通过方法3分类的FSS儿童的平均AH SDS接近平均TH SDS。
