Ma Chenhui, Gao Lei, Song Kewei, Gu Baohong, Wang Bofang, Pu Weigao, Chen Hao
The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou, China; Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou, China.
Biomol Biomed. 2024 Dec 11;25(1):1-15. doi: 10.17305/bb.2024.10887.
Gastric cancer (GC) remains a significant global health challenge, particularly prevalent in East Asia. Despite advancements in various treatment modalities, the prognosis for patients, especially those in advanced stages, remains poor, highlighting the need for innovative therapeutic approaches. This review explores the promising potential of diterpenes, naturally occurring compounds with robust anticancer properties, derived from diverse sources such as plants, marine organisms, and fungi. Diterpenes have shown the ability to influence reactive oxygen species (ROS) generation, ferroptosis, and autophagy, positioning them as attractive candidates for novel cancer therapies. This review explores the mechanisms of action of diterpenes and their clinical implications for the treatment of GC. Additionally, it addresses the challenges in translating these compounds from preclinical studies to clinical applications, emphasizing the need for further research to enhance their therapeutic profiles and minimize potential side effects. The discussion underscores the importance of diterpenes in future anticancer strategies, particularly in the fight against gastric cancer.
胃癌（GC）仍然是一项重大的全球健康挑战，在东亚地区尤为普遍。尽管各种治疗方式取得了进展，但患者的预后，尤其是晚期患者的预后仍然很差，这凸显了创新治疗方法的必要性。本综述探讨了二萜类化合物的潜在前景，二萜类是具有强大抗癌特性的天然存在的化合物，其来源多样，包括植物、海洋生物和真菌。二萜类已显示出影响活性氧（ROS）生成、铁死亡和自噬的能力，使其成为新型癌症治疗的有吸引力的候选药物。本综述探讨了二萜类的作用机制及其对胃癌治疗的临床意义。此外，它还讨论了将这些化合物从临床前研究转化为临床应用所面临的挑战，强调需要进一步研究以改善其治疗效果并将潜在副作用降至最低。讨论强调了二萜类在未来抗癌策略中的重要性，特别是在对抗胃癌方面。
