生长抑素对腺苷-3',5'-单磷酸刺激的肝脏核糖体蛋白合成的抑制作用。
Inhibition by somatostatin of adenosine-3',5'-monophosphate stimulated hepatic ribosomal protein synthesis.
作者信息
Tragl K H, Kinast H
出版信息
Klin Wochenschr. 1977 Jul 15;55(14):707-9. doi: 10.1007/BF01478838.
Somatostatin which inhibits the secretion of various pituitary and intestinal hormones has been suspected to exert these effects by inhibiting adenosine-3',5'-monophosphate accumulation in the respective endocrine gland. Our results, obtained by cell free protein synthesis and by sedimentation through sucrose gradients of ribosomes, prepared from rat liver after incubation with cyclic AMP and/or somatostatin also suggest this antagonism between somatostatin and cyclic AMP. In addition, they indicate that this antagonism is not restricted to endocrine tissues.
生长抑素可抑制多种垂体和肠道激素的分泌，人们怀疑它是通过抑制相应内分泌腺中3',5'-单磷酸腺苷的积累来发挥这些作用的。我们通过无细胞蛋白质合成以及用环磷酸腺苷和/或生长抑素孵育后的大鼠肝脏制备的核糖体在蔗糖梯度中沉降所获得的结果，也表明了生长抑素与环磷酸腺苷之间存在这种拮抗作用。此外，这些结果还表明这种拮抗作用并不局限于内分泌组织。
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