UCL-Eastman Dental Institute, University College London, UK.
Cell Stress Chaperones. 2010 Mar;15(2):123-41. doi: 10.1007/s12192-009-0137-6.
In recent years, it has been hypothesised that a new signalling system may exist in vertebrates in which secreted molecular chaperones form a dynamic continuum between the cellular stress response and corresponding homeostatic physiological mechanisms. This hypothesis seems to be supported by the finding that many molecular chaperones are released from cells and act as extracellular signals for a range of cells. However, this nascent field of biological research seems to suffer from an excessive criticism that the biological activities of molecular chaperones are due to undefined components of the microbial expression hosts used to generate recombinant versions of these proteins. In this article, a number of the proponents of the cell signalling actions of molecular chaperones take this criticism head-on. They show that sufficient evidence exists to support fully the hypothesis that molecular chaperones have cell-cell signalling actions that are likely to be part of the homeostatic mechanism of the vertebrate.
近年来，人们假设脊椎动物中可能存在一种新的信号系统，其中分泌的分子伴侣在细胞应激反应和相应的体内平衡生理机制之间形成动态连续体。这一假设似乎得到了以下发现的支持：许多分子伴侣从细胞中释放出来，并作为细胞外信号作用于一系列细胞。然而，这个新兴的生物学研究领域似乎受到了过多的批评，即分子伴侣的生物学活性是由于用于生成这些蛋白质的重组版本的微生物表达宿主中未定义的成分。在本文中，一些分子伴侣细胞信号作用的支持者直面这些批评。他们表明，存在充分的证据支持这样的假设，即分子伴侣具有细胞间信号作用，这可能是脊椎动物体内平衡机制的一部分。
