单头尼泊尔香青精油的化学成分及抗菌活性

Chemical composition and antimicrobial activity of the essential oil of Anaphalis nubigena var. monocephala.

作者信息

Joshi Rajesh K, Pande Chitra, Mujawar Mohammad H K, Kholkute Sanjiva D

机构信息

Regional Medical Research Center, Indian Council of Medical Research, Belgaum, Karnataka-590 010, India.

出版信息

Nat Prod Commun. 2009 Jul;4(7):993-6.

PMID:19731610

Abstract

The essential oil composition of the aerial parts of Anaphalis nubigena DC. var. monocephala (DC.) C. B. Clarke collected from Pindari glacier at a height of 3300 m, was analyzed by using GC and GC/MS. Sixty components were identified, accounting for 95.9% of the total oil. The main constituents were alpha-guaiene (12.3%), gamma-muurolene (10.4%), gamma-cadinene (8.3%), alpha-muurolol (7.4%), alpha-gurjunene (6.0%) and alpha-bulnesene (5.8%). The oil was found to be rich in sesquiterpene hydrocarbons (60.1%). The oil was active against Escherichia coli (NCIM 2065) and Klebsiella pneumoniae (NCIM 2957), with MIC values of 125 microg/mL and 500 microg/mL, respectively.

摘要

对采自海拔3300米的品达里冰川的单头香青（Anaphalis nubigena DC. var. monocephala (DC.) C. B. Clarke）地上部分的精油成分进行了气相色谱（GC）和气相色谱-质谱联用（GC/MS）分析。共鉴定出60种成分，占总油含量的95.9%。主要成分有α-愈创木烯（12.3%）、γ-衣兰油烯（10.4%）、γ-杜松烯（8.3%）、α-衣兰油醇（7.4%）、α-古芸烯（6.0%）和α-布藜烯（5.8%）。该油富含倍半萜烃类（60.1%）。该油对大肠杆菌（NCIM 2065）和肺炎克雷伯菌（NCIM 2957）有活性，其最低抑菌浓度（MIC）值分别为125微克/毫升和500微克/毫升。