3-氨基-1,2,4-三唑合成的高效方法
Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles.
作者信息
Noël Romain, Song Xinyi, Jiang Rong, Chalmers Michael J, Griffin Patrick R, Kamenecka Theodore M
机构信息
Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way No. A2A, Jupiter, Florida 33458, USA.
出版信息
J Org Chem. 2009 Oct 2;74(19):7595-7. doi: 10.1021/jo9016502.
Abstract
A general and efficient method for the preparation of 3-amino-1,2,4-triazoles has been developed. The desired 3-amino-1,2,4-triazoles (1) were prepared in good overall yield via two convergent routes. The key intermediate within both routes is substituted hydrazinecarboximidamide derivative 2.
摘要
已开发出一种制备3-氨基-1,2,4-三唑的通用且高效的方法。所需的3-氨基-1,2,4-三唑（1）通过两条汇聚路线以良好的总收率制备。两条路线中的关键中间体均为取代的肼甲脒衍生物2。
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