Fenstersheib M D, Miller M, Diggins C, Liska S, Detwiler L, Werner S B, Lindquist D, Thacker W L, Benson R F
Santa Clara County Health Department, San Jose, California 95128.
Lancet. 1990 Jul 7;336(8706):35-7. doi: 10.1016/0140-6736(90)91532-f.
An outbreak of Pontiac fever occurred among 34 of 56 people attending conferences at a hotel in Santa Clara County, California, in 1988. Two groups had an acute febrile upper respiratory illness, with a mean attack rate of 82% and a mean incubation period of 56 hours. Symptoms resolved spontaneously within 5 days. Legionella anisa, which had not previously been associated with outbreaks of Pontiac fever or legionnaires' disease, was isolated from a decorative fountain in the hotel lobby. In addition, 5 of 8 pairs of serum samples from cases showed a more than fourfold rise in antibody titre to the L anisa recovered from the fountain. 42% of hotel employees had titres greater than or equal to 256 against L anisa, whereas none of 48 serum samples from matched controls had titres greater than or equal to 128. The findings raise concern about water treatment protocols for extent of disease that might be caused by exposure to aerosols containing L anisa and other Legionella species.
1988年，在加利福尼亚州圣克拉拉县一家酒店参加会议的56人中，有34人爆发了庞蒂亚克热。两组人都出现了急性发热性上呼吸道疾病，平均发病率为82%，平均潜伏期为56小时。症状在5天内自行缓解。从酒店大堂的一个装饰性喷泉中分离出了以前未曾与庞蒂亚克热或军团病暴发相关的阿氏军团菌。此外，8例病例的血清样本中有5例对从喷泉中分离出的阿氏军团菌的抗体滴度升高了四倍以上。42%的酒店员工针对阿氏军团菌的滴度大于或等于256，而48份配对对照血清样本中无一例滴度大于或等于128。这些发现引发了人们对水处理方案的担忧，因为接触含有阿氏军团菌和其他军团菌属的气溶胶可能导致疾病传播。
