Inoue Hospital, Nagasaki 850-0045, Japan.
Respirology. 2009 Nov;14(8):1206-8. doi: 10.1111/j.1440-1843.2009.01619.x. Epub 2009 Sep 1.
A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated.
一位 28 岁女性因社区获得性肺炎接受了舒巴坦/氨苄西林和克拉霉素治疗，但 4 天后未见明显改善。抗生素方案改为帕珠沙星，临床迅速改善。鉴定出病原体为肺炎支原体，分离株中 23S rRNA 结构域 V 第 2063 位腺嘌呤（A）到鸟嘌呤（G）突变。该分离株对包括克拉霉素在内的大环内酯类抗生素的最小抑菌浓度显著升高。
