Li Chaoyang, Ford Earl S, Huang Terry T-K, Sun Shumei S, Goodman Elizabeth
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA. 30341.cli@cdc
J Pediatr. 2009 Sep;155(3):S5.e9-16. doi: 10.1016/j.jpeds.2009.04.046.
To examine the patterns of change in cardiometabolic risk factors associated with the metabolic syndrome in children and adolescents between the ages of 8 to 19 years.
Data of children and adolescents who participated in the Fels Longitudinal Study were analyzed. Body mass index, waist circumference, fasting insulin, fasting glucose, triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, and diastolic blood pressure were assessed annually with a standardized protocol.
The proportion of participants having at least 1 change between states of high and normal risk ranged from of 11.0% for body mass index to 30.4% for triglycerides. Youth in the high-risk category at baseline had a higher proportion having changed their status for all risk factors (all P < .05) except waist circumference compared with those in the normal-risk category. There were significant time effects for all risk factors (all P < .01) except fasting glucose and triglyceride levels in metric scores, but insignificant time effects for all risk factors in Z-scores in growth curve analyses.
The cardiometabolic risk factors associated with the MetS were relatively stable among white children and adolescents in the normal risk category. Changes in status were common if the risk factor was elevated.
研究8至19岁儿童和青少年中与代谢综合征相关的心血管代谢危险因素的变化模式。
分析参与费尔斯纵向研究的儿童和青少年的数据。采用标准化方案每年评估体重指数、腰围、空腹胰岛素、空腹血糖、甘油三酯、高密度脂蛋白胆固醇、收缩压和舒张压。
在高风险和正常风险状态之间至少有1项变化的参与者比例，体重指数为11.0%，甘油三酯为30.4%。与正常风险组相比，基线时处于高风险类别的青少年在所有危险因素（腰围除外）中改变状态的比例更高（所有P < 0.05）。在指标得分中，除空腹血糖和甘油三酯水平外，所有危险因素均有显著的时间效应（所有P < 0.01），但在生长曲线分析中，Z得分的所有危险因素时间效应不显著。
在正常风险类别的白人儿童和青少年中，与代谢综合征相关的心血管代谢危险因素相对稳定。如果危险因素升高，状态变化很常见。
