Chun Ruthanne
University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI 53706, USA.
Top Companion Anim Med. 2009 Aug;24(3):157-62. doi: 10.1053/j.tcam.2009.03.003.
Lymphoma is the most common hematologic neoplasm of dogs. Although the order of drug administration and duration of the maintenance portion of the protocol vary considerably, most oncologists agree that a doxorubicin-based (eg, CHOP) combination chemotherapy protocol provides the longest period of disease control and overall survival. The use of a prolonged maintenance phase is no longer recommended, but consolidation therapy may prove to be of benefit. Further, combination of chemotherapy with half- or whole-body radiation therapy or even bone marrow transplant is advocated by some institutions. The goal of this article is to summarize the current literature regarding chemotherapy for dogs with high-grade lymphoma and provide recommendations for therapy in a variety of different scenarios.
淋巴瘤是犬类最常见的血液肿瘤。尽管给药顺序和方案维持阶段的时长差异很大，但大多数肿瘤学家都认为，基于阿霉素的（如CHOP）联合化疗方案能提供最长的疾病控制期和总生存期。不再推荐使用延长的维持期，但巩固治疗可能被证明是有益的。此外，一些机构主张将化疗与半身或全身放射治疗甚至骨髓移植相结合。本文的目的是总结目前关于犬高级别淋巴瘤化疗的文献，并针对各种不同情况提供治疗建议。
