Department of Neurology, Vanderbilt University, Nashville, TN 37232-8552, USA.
Neurotoxicology. 2009 Nov;30(6):996-9. doi: 10.1016/j.neuro.2009.08.008. Epub 2009 Sep 2.
Neurodegeneration of the central and peripheral nervous system associated with hypocupremia and hyperzincinemia has been widely recognized but the origin of high zinc remained unknown. Denture cream has been recently suggested as one possible source of zinc, but the frequency with which denture fixative alone accounts for this syndrome is unknown. We analyzed the origin of excessive zinc in eleven patients with a progressive myelopolyneuropathy and unexplained hypocupremia with hyperzincinemia. These patients had a detailed clinical assessment, determination of zinc and copper levels, and analyzed use of denture cream with the estimates of daily zinc exposure. We identified denture cream as a source of excessive zinc in 100% patients in our cohort. They all had a history of ill-fitting dentures requiring large amounts of denture cream, resulting in significant zinc exposure. Their copper and zinc normalized after stopping denture cream, further confirming that this is the source of high zinc. Inappropriate use of denture cream appears to be the sole source of excessive zinc in these patients.
中枢和周围神经系统的神经退行性变与低铜血症和高锌血症有关，这已得到广泛认可，但高锌的来源仍不清楚。义齿膏最近被认为是锌的一个可能来源，但仅义齿固定剂就导致这种综合征的频率尚不清楚。我们分析了 11 例进行性多发性神经病和原因不明的低铜血症伴高锌血症患者中过量锌的来源。这些患者接受了详细的临床评估、锌和铜水平的测定，并分析了义齿膏的使用情况及其每日锌暴露量的估计值。我们发现义齿膏是我们队列中 100%患者过量锌的来源。他们都有假牙不合适的病史，需要大量的义齿膏，导致大量的锌暴露。停用义齿膏后，他们的铜和锌恢复正常，进一步证实这就是高锌的来源。义齿膏使用不当似乎是这些患者体内过量锌的唯一来源。
