Institut UTINAMB, UMR CNRS 6213, Faculté des Sciences, La Bouloie, Université de Franche-comté, Besançon Cedex, France.
J Biotechnol. 2009 Oct 26;144(2):96-101. doi: 10.1016/j.jbiotec.2009.08.016. Epub 2009 Sep 2.
Calculations of the interaction energy and dielectric responses of single-walled carbon nanotubes to the presence of amino acid inside (encapsulation) or outside (adsorption) the nanotube are carried out. It is shown that the frequency shifts of selected nanotubes conveniently tailored to the size of the probed molecules and used in a resonator configuration can selectively detect the position (encapsulated or adsorbed in the tube) of different species. We demonstrate in particular that adsorption outside the nanotube is better detected than encapsulation whatever the amino acid tested. Without explicitly dealing with drug delivery, these calculations represent the first step toward the detection of amino acids encapsulation in potential drug vector.
对单壁碳纳米管内（封装）或外（吸附）存在氨基酸时的相互作用能和介电响应进行了计算。结果表明，选择的、大小适合探测分子的纳米管的频率位移，在谐振腔结构中使用时，可以选择性地检测不同物质的位置（封装或吸附在管内）。我们特别证明，无论测试的氨基酸如何，纳米管外的吸附都比封装更容易被检测到。这些计算虽然没有明确涉及药物输送，但代表了对潜在药物载体中氨基酸封装检测的第一步。
