Department of Psychology, University of Toronto, 100 St. George Street, Toronto, Ontario, Canada.
Neuroimage. 2010 Jan 1;49(1):905-13. doi: 10.1016/j.neuroimage.2009.08.049. Epub 2009 Sep 2.
Evidence from cognitive, patient and neuroimaging research indicates that "remembering to remember" intentions, i.e., prospective memory (PM) retrieval, requires both general memory systems involving the medial temporal lobes and an executive system involving rostral PFC (BA 10). However, it is not known how prospective memories are initially formed. Using fMRI, we investigated whether brain activity during encoding of future intentions and present actions differentially predicted later memory for those same intentions (PM) and actions (retrospective memory). We identified two significant patterns of neural activity: a network linked to overall memory and another linked specifically to PM. While overall memory success was predicted by temporal lobe activations that included the hippocampus, PM success was also uniquely predicted by activations in additional regions, including left rostrolateral PFC and the right parahippocampal gyrus. This finding extends the role of these structures to the formation of individual intentions. It also provides the first evidence that PM encoding, like PM retrieval, is supported by both a common episodic memory network and an executive network specifically recruited by future-oriented processing.
认知、患者和神经影像学研究的证据表明，“记得要记得”的意图，即前瞻性记忆 (PM) 检索，既需要涉及内侧颞叶的一般记忆系统，也需要涉及额前皮质 (BA 10) 的执行系统。然而，目前尚不清楚前瞻性记忆是如何最初形成的。我们使用 fMRI 研究了在编码未来意图和当前动作期间的大脑活动是否会不同地预测对这些相同意图（PM）和动作（回溯记忆）的后期记忆。我们确定了两种显着的神经活动模式：与整体记忆相关的网络和与 PM 相关的特定网络。虽然整体记忆的成功可以通过包括海马体在内的颞叶激活来预测，但 PM 的成功也可以通过包括左侧额外侧 PFC 和右侧海马旁回在内的其他区域的激活来独特地预测。这一发现将这些结构的作用扩展到单个意图的形成。它还首次提供了证据，表明 PM 编码与 PM 检索一样，既由共同的情景记忆网络支持，也由未来导向处理专门招募的执行网络支持。
