Fundación Ciencia para la Vida, Santiago, Chile.
J Neuroimmunol. 2009 Nov 30;216(1-2):8-19. doi: 10.1016/j.jneuroim.2009.07.018. Epub 2009 Sep 4.
Dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental roles in controlling immunity, DCs and T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediate interactions into the nervous system, but can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DC and T-cell physiology and, in turn, immune response. Moreover, we discuss how alterations in the dopamine-mediated immune regulatory mechanisms could contribute to the onset of immune-related disorders.
树突状细胞（DCs）负责激活 T 细胞，并促使其从幼稚 T 细胞分化为合适的效应细胞。由于它们在控制免疫方面的重要作用，DC 和 T 细胞需要严格的调控机制。有几项研究表明，多巴胺不仅介导神经系统的相互作用，还可以调节免疫。在这里，我们回顾了这种神经递质作为调节 DC 和 T 细胞生理功能以及免疫反应的新兴作用。此外，我们还讨论了多巴胺介导的免疫调节机制的改变如何导致免疫相关疾病的发生。
