Prado Carolina, Bernales Sebastian, Pacheco Rodrigo
Fundacion Ciencia y Vida. Avenida Zanartu #1482, Santiago, Chile.
Endocr Metab Immune Disord Drug Targets. 2013 Jun;13(2):184-94. doi: 10.2174/1871530311313020007.
CD4+ T-cells are central players orchestrating antigen-specific immunity and tolerance. Importantly, dendritic cells (DCs) are responsible for priming T-cells and for promoting their differentiation from naïve T-cells into appropriate functional cells. Because of their fundamental roles in controlling immunity, activation and differentiation of DCs and CD4+ T-cells require tight regulatory mechanisms. Several studies have shown that dopamine, not only mediates interactions into the nervous system, but it can also contribute to the modulation of immunity. Here, we review the emerging role of this neurotransmitter as a regulator of DCs and CD4+ T-cells physiology and its consequent involvement, in the regulation of immune response. We specially focus the analysis in the role of dopamine receptor D5 expressed on DCs and CD4+ T-cells in the modulation of immunity. We also discuss how alterations in the dopamine-mediated regulation of immunity could contribute to the onset and development of immune-related disorders.
CD4+ T细胞是协调抗原特异性免疫和耐受性的核心参与者。重要的是，树突状细胞（DCs）负责启动T细胞，并促进其从初始T细胞分化为适当的功能细胞。由于它们在控制免疫方面的基本作用，DCs和CD4+ T细胞的激活和分化需要严格的调节机制。多项研究表明，多巴胺不仅介导进入神经系统的相互作用，还可有助于调节免疫。在此，我们综述了这种神经递质作为DCs和CD4+ T细胞生理学调节剂的新作用及其在免疫反应调节中的相应参与。我们特别关注分析DCs和CD4+ T细胞上表达的多巴胺受体D5在免疫调节中的作用。我们还讨论了多巴胺介导的免疫调节改变如何可能导致免疫相关疾病的发生和发展。
