Aging Research Center, NVS Department, Karolinska Institutet, Gävlegatan 16, Stockholm, Sweden.
Neurobiol Aging. 2011 Jul;32(7):1336-7. doi: 10.1016/j.neurobiolaging.2009.08.002. Epub 2009 Sep 4.
We explored the association of chronic AF with stroke, dementia and Alzheimer's disease (AD) among community-dwelling elderly people. The study population consisted of 685 individuals from Stockholm (The Kungsholmen Project) who were aged 78 years and were free of dementia and clinical stroke. During the 6-year follow-up, 170 subjects developed dementia, and 86 persons experienced first-ever stroke. The incidence rate (per 1000 person-years) of dementia, AD and first-ever stroke was 72.3, 52.2, and 52.2 in persons with AF and 63.8, 54.6 and 30.6 in those without AF, respectively. AF was associated with the hazard ratio of 1.8 (95%CI, 1.0-3.4) for first-ever stroke, but not significantly associated with dementia or AD.
我们探讨了慢性心房颤动（AF）与社区居住的老年人中风、痴呆和阿尔茨海默病（AD）之间的关系。研究人群由来自斯德哥尔摩（Kungsholmen 项目）的 685 名年龄为 78 岁且无痴呆和临床中风的个体组成。在 6 年的随访期间，170 名受试者发生了痴呆，86 名受试者发生了首次中风。在有 AF 的人群中，痴呆、AD 和首次中风的发生率（每 1000 人年）分别为 72.3、52.2 和 52.2，而在没有 AF 的人群中，发生率分别为 63.8、54.6 和 30.6。AF 与首次中风的风险比为 1.8（95%CI，1.0-3.4）相关，但与痴呆或 AD 无显著相关性。
