Institute for Molecular Bioscience, The University of Queensland, Brisbane, Qld 4072, Australia.
Int J Biochem Cell Biol. 2010 Mar;42(3):445-8. doi: 10.1016/j.biocel.2009.08.017. Epub 2009 Sep 3.
SoxF genes (Sox7, Sox17 and Sox18) encode a group of transcription factors that have a pivotal role in cardio-vascular development. SOXF factors orchestrate endothelial cell fate or direct cell differentiation in developing heart, blood vessels and lymphatic vessels. Their roles are highly conserved throughout animal evolution. SOXF activity is finely tuned with a variety of cell type-specific co-factors and partner proteins to effect transcription of genes critical for endothelial cell phenotype and function. Because SOXF factors play a central role in cardiogenesis, vasculogenesis and lymphangiogenesis, SOXF gene mutations figure prominently in the aetiology of human vascular disease.
SoxF 基因（Sox7、Sox17 和 Sox18）编码一组转录因子，它们在心血管发育中起着关键作用。SOXF 因子协调内皮细胞命运或在发育中的心脏、血管和淋巴管中直接细胞分化。它们的作用在动物进化过程中高度保守。SOXF 活性通过多种细胞类型特异性辅助因子和伙伴蛋白进行精细调节，以影响内皮细胞表型和功能的关键基因的转录。由于 SOXF 因子在心脏发生、血管发生和淋巴管发生中起着核心作用，SOXF 基因突变在人类血管疾病的发病机制中起着重要作用。
