Institute for Medical Microbiology, Georg-August-University, Kreuzbergring 57, D-37075 Göttingen, Germany.
Microbes Infect. 2009 Nov;11(13):1079-87. doi: 10.1016/j.micinf.2009.08.011. Epub 2009 Sep 4.
Programmed cell death is an essential mechanism of the host to combat infectious agents and to regulate immunity during infection. Consequently, activation and deactivation of the hosts' cell death pathways by protozoan parasites play critical roles in parasite control, pathogenesis, immune evasion and parasite dissemination within the host. Here, we discuss advances in the understanding of these fascinating host-parasite interactions with special emphasis on how protozoa can modulate the cell death apparatus of its host.
程序性细胞死亡是宿主对抗感染因子和调节感染期间免疫的一种重要机制。因此，原生动物寄生虫激活和失活宿主的细胞死亡途径在寄生虫控制、发病机制、免疫逃避和寄生虫在宿主内传播中起着关键作用。在这里，我们讨论了对这些迷人的宿主-寄生虫相互作用的理解的进展，特别强调了原生动物如何调节宿主的细胞死亡装置。
