Laboratório de Pesquisa em Leishmaniose, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
J Proteomics. 2011 Dec 10;75(1):246-56. doi: 10.1016/j.jprot.2011.07.027. Epub 2011 Aug 6.
Protozoan parasites are responsible for an impressive disease burden in developing and less-developed countries. The development of vaccines and effective new therapies for dealing with these organisms are among the main gaps to be filled in the control of protozoan parasite diseases. Programmed cell death (PCD) pathways have gained attention in recent years because they comprise complex signalling pathways that can be explored for therapeutic developments. In addition, high-resolution proteomics approaches offer the opportunity to determine protein patterns associated with either cell survival or cell death. This review will focus on proteomics studies of PCD mechanisms during host-protozoan parasite interactions.
原生动物寄生虫在发展中国家和欠发达国家造成了巨大的疾病负担。开发疫苗和有效的新疗法来应对这些生物体是控制原生动物寄生虫病的主要空白之一。程序性细胞死亡 (PCD) 途径近年来受到关注，因为它们包含复杂的信号通路，可以探索用于治疗开发。此外，高分辨率蛋白质组学方法提供了确定与细胞存活或细胞死亡相关的蛋白质模式的机会。本综述将重点介绍宿主-原生动物寄生虫相互作用过程中 PCD 机制的蛋白质组学研究。
