[吡拉西坦对麻醉性镇痛药效果的影响]
[The influence of piracetam on the effects of narcotic analgesics].
作者信息
Chichenkov O N, Krylova I N, Borozdin M Iu, Pokatilov D V
出版信息
Farmakol Toksikol. 1990 Mar-Apr;53(2):22-4.
In experiments on white male mice there was studied the influence of piracetam (250-300 mg/kg) on the analgesic effect of ligands of different types of opioid receptors (morphine, 7.5 mg/kg, DADLE, 7.5 mg/kg, pentazocine, 15 mg/kg) and also on the action of morphine concerning the cardiovascular system and respiration. Piracetam was shown to possess the antagonistic properties with respect to some effects of morphine, however they are not of the universal character and do not depend on the interaction with a certain type of opioid receptors.
在对雄性白色小鼠进行的实验中，研究了吡拉西坦（250 - 300毫克/千克）对不同类型阿片受体配体（吗啡，7.5毫克/千克；DADLE，7.5毫克/千克；喷他佐辛，15毫克/千克）镇痛作用的影响，以及对吗啡在心血管系统和呼吸方面作用的影响。结果表明，吡拉西坦对吗啡的某些作用具有拮抗特性，然而这些特性并非普遍存在，且不依赖于与特定类型阿片受体的相互作用。
Zotero 插件