Department of Nursing Studies, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Eur J Oncol Nurs. 2010 Feb;14(1):17-22. doi: 10.1016/j.ejon.2009.07.005. Epub 2009 Sep 5.
The aim of the study was to examine anxiety and depression and their effects on the quality of life (QOL) of patients with breast cancer undergoing chemotherapy or radiotherapy.
A cross-sectional descriptive design was used. Data were collected from a self-report survey derived from the Hospital Anxiety and Depression Scale (HADS)-Cantonese/Chinese version, the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B)-Chinese version, and from demographic and clinical characteristics. Chi-square tests and the General Linear Model (GLM) were used for secondary data analysis.
The study group consisted of 218 women (> or = 18 years old) who were midway through chemotherapy or radiotherapy for stage I-III breast cancer. All subjects were recruited from the outpatient sections of the Departments of Clinical Oncology or Breast Centers of the four Hong Kong public hospitals.
The percentage of participants with anxiety (chi2=6.56, p=0.01) or depression (chi2=7.26, p=0.007) was higher in the chemotherapy group. More participants in the chemotherapy group had both anxiety and depression than those in the radiotherapy group, though no statistically significant difference was reported. Anxiety and depression had detrimental effects on the overall and other domains of QOL of these women undergoing adjuvant therapy for breast cancer.
This study should increase nurses' awareness of the importance of integrating psychological symptom assessment into nursing assessment procedures, and enhance their clinical sensitivity in identifying high-risk groups of patients undergoing specific cancer treatments.
本研究旨在探讨接受化疗或放疗的乳腺癌患者的焦虑和抑郁状况及其对生活质量（QOL）的影响。
采用横断面描述性设计。数据来自医院焦虑和抑郁量表（HADS）-广东话/中文版本、乳腺癌癌症治疗功能评估（FACT-B）-中文版本的自我报告调查，以及人口统计学和临床特征。采用卡方检验和一般线性模型（GLM）进行二次数据分析。
研究组包括 218 名（年龄≥18 岁）正在接受 I-III 期乳腺癌化疗或放疗的女性。所有受试者均来自香港四家公立医院临床肿瘤科或乳腺中心的门诊科室招募。
化疗组中出现焦虑（卡方=6.56，p=0.01）或抑郁（卡方=7.26，p=0.007）的参与者比例较高。与放疗组相比，化疗组中同时出现焦虑和抑郁的患者更多，但无统计学差异。焦虑和抑郁对接受乳腺癌辅助治疗的这些女性的整体和其他生活质量领域都有不利影响。
本研究应提高护士对将心理症状评估纳入护理评估程序的重要性的认识，并增强他们在识别接受特定癌症治疗的高危患者群体方面的临床敏感性。
