Jippo Tomoko, Kobayashi Yuko, Sato Harumi, Hattori Atsushi, Takeuchi Hiroaki, Sugimoto Keiichiro, Shigekawa Munekazu
Department of Food and Nutrition, Faculty of Human Life Sciences, Senri Kinran University, 5-25-1 Fujishirodai, Suita, Osaka 565-0873, Japan.
Biosci Biotechnol Biochem. 2009 Sep;73(9):2110-2. doi: 10.1271/bbb.90205. Epub 2009 Sep 7.
This study investigated the effects of guarana seed extract (GSE) on an anti-allergic mechanism. GSE orally administered inhibited the anti-dinitrophenol IgE-induced passive cutaneous anaphylaxis reaction in mice. Furthermore, it inhibited the degranulation of rat basophilic leukemia RBL-2H3 cells. It had no cytotoxicity on RBL-2H3 cells. These results show that GSE is a candidate for effective therapeutic material for allergic diseases.
本研究调查了瓜拉那籽提取物（GSE）对抗过敏机制的影响。口服GSE可抑制二硝基苯酚IgE诱导的小鼠被动皮肤过敏反应。此外，它还抑制大鼠嗜碱性白血病RBL-2H3细胞的脱颗粒。它对RBL-2H3细胞没有细胞毒性。这些结果表明，GSE是过敏性疾病有效治疗材料的候选者。
