Department of Infectious Diseases, Helsingor Hospital, Helsingor, Denmark.
Sex Transm Dis. 2010 Jan;37(1):49-52. doi: 10.1097/OLQ.0b013e3181b6f284.
Studies indicate that antiretroviral postexposure prophylaxis (PEP) after sexual exposure to HIV reduce the risk of infection considerably. Since 1998 PEP after sexual HIV exposure within the preceding 24 hours, has been available in Denmark. PEP can only be prescribed at clinical centers with specialists experienced in HIV treatment. The objective of this study is to describe the use of PEP after sexual exposure from 1998 to 2006.
The Danish PEP registry collects data from all cases of PEP use in Denmark after exposure to HIV through a structured questionnaire.
There were 374 cases of PEP use after sexual exposure. The incidence increased from 5 cases in 1997 to 87 in 2006. PEP was used by heterosexuals (40%) as well as men who have sex with men (57%). The HIV-status of the source was unknown in 41% of the cases of which 90% involved a source belonging to a high risk group, and 63% involved exposure by receptive anal intercourse. PEP was administered within 24 hours in 95% of the cases and the median time to initiation (N = 225) was 11.0 hours (range 0.5-60.0). PEP was completed by 65%.
This nationwide study showed a steady but moderate increase in the use of PEP after sexual HIV-exposure from 1998 to 2006. Time to initiation of PEP was low and the PEP prescription practice was targeted toward high risk exposures.
研究表明，在 HIV 性接触后使用抗逆转录病毒暴露后预防（PEP）可大大降低感染风险。自 1998 年以来，在丹麦，对于 24 小时内发生的 HIV 性接触暴露，已经可以提供 PEP。PEP 只能在具有 HIV 治疗经验的专家的临床中心开具。本研究的目的是描述 1998 年至 2006 年期间因性接触而使用 PEP 的情况。
丹麦的 PEP 登记处通过结构化问卷从丹麦所有使用 PEP 的病例中收集数据。
共有 374 例因性接触而使用 PEP。发病率从 1997 年的 5 例增加到 2006 年的 87 例。PEP 的使用者包括异性恋者（40%）和男男性接触者（57%）。在 41%的情况下，暴露源的 HIV 状态未知，其中 90%涉及属于高风险群体的来源，63%涉及接受性肛交暴露。在 95%的情况下，PEP 在 24 小时内给予，中位开始时间（N=225）为 11.0 小时（范围 0.5-60.0）。有 65%的人完成了 PEP。
这项全国性研究表明，1998 年至 2006 年期间，因 HIV 性接触而使用 PEP 的情况稳步但适度增加。PEP 的起始时间较短，PEP 处方的目标是高危暴露。
