Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Sex Transm Dis. 2009 Dec;36(12):738-44. doi: 10.1097/OLQ.0b013e3181b38a4b.
To estimate the association between Trichomonas vaginalis infection (TV) and 6 sexually transmitted infections: chlamydia, gonorrhea, herpes simplex virus (Types 1 and 2), syphilis, and human immunodeficiency virus (HIV) in a nationally representative sample.
We used data from the National Health and Nutrition Examination Survey combining the 2001-2002 and 2003-2004 waves to estimate the association between TV and sexually transmitted infections (STIs) among women in the civilian, noninstitutionalized US population. The final sample included data from 3648 women, which when weighted, represents the experience of 65,563,298 US women between the ages of 14 and 49. Crude and adjusted relative risks were estimated using logistic regression for rare STIs (<10%; chlamydia, syphilis, and HIV) and Poisson regression for common STIs (herpes simplex virus [HSV] Types 1 and 2). Statistical analyses were conducted using Stata (version 9.2).
The prevalence of trichomoniasis was 3.2% with over 80% of cases asymptomatic in the past month. All STIs examined (chlamydia, gonorrhea, HSV-1, HSV-2, syphilis, and HIV) were more common among women with a positive test for trichomoniasis. HSV-1 (RR = 1.20, 95% CI: 1.09, 1.34) and HSV-2 (RR = 1.51, 95% CI: 2.32, 3.23) were significantly associated with trichomoniasis after adjusting for race/ethnicity, age, and recent sexual partners. In crude analyses, a positive treponemal test was 6 times (95% CI: 2.07, 18.8) more common and HIV was 13 times (95% CI: 2.88, 59.1) more common among women with trichomoniasis, but these estimates were greatly attenuated after adjustment for potential confounders.
Trichomoniasis is significantly associated with concurrent STI.
为了在具有全国代表性的样本中评估阴道毛滴虫感染（TV）与 6 种性传播感染（衣原体、淋病、单纯疱疹病毒[1 型和 2 型]、梅毒和人类免疫缺陷病毒[HIV]）之间的关联。
我们使用了结合了 2001-2002 年和 2003-2004 年两个波次的数据的国家健康和营养调查（NHANES）数据，以评估非住院的美国平民人口中女性中 TV 与性传播感染（STI）之间的关联。最终样本包括 3648 名女性的数据，经加权处理后，代表了年龄在 14 至 49 岁之间的 65563298 名美国女性的经历。对于罕见的 STI（<10%：衣原体、梅毒和 HIV），我们使用逻辑回归估计了未经调整和调整后的相对风险，对于常见的 STI（单纯疱疹病毒[HSV]1 型和 2 型），我们使用泊松回归进行了估计。使用 Stata（版本 9.2）进行了统计分析。
滴虫病的患病率为 3.2%，过去一个月中超过 80%的病例无症状。所有检查的 STI（衣原体、淋病、HSV-1、HSV-2、梅毒和 HIV）在滴虫病检测呈阳性的女性中更为常见。在调整了种族/民族、年龄和最近的性伴侣后，HSV-1（RR=1.20，95%CI：1.09，1.34）和 HSV-2（RR=1.51，95%CI：2.32，3.23）与滴虫病显著相关。在粗分析中，梅毒阳性检测的发生频率高 6 倍（95%CI：2.07，18.8），HIV 的发生频率高 13 倍（95%CI：2.88，59.1），但在调整了潜在的混杂因素后，这些估计值大大降低。
滴虫病与同时存在的 STI 显著相关。
