Manna Uttam, Patil Satish
Solid State and Structural Chemistry Unit Indian Institute of Science, Bangalore-560012, India.
Langmuir. 2009 Sep 15;25(18):10515-22. doi: 10.1021/la901243m.
The integration of hydrophobic and hydrophilic drugs in the polymer microcapsule offers the possibility of developing a new drug delivery system that combines the best features of these two distinct classes of material. Recently, we have reported the encapsulation of an uncharged water-insoluble drug in the polymer membrane. The hydrophobic drug is deposited using a layer-by-layer (LbL) technique, which is based on the sequential adsorption of oppositely charged polyelectrolytes onto a charged substrate. In this paper, we report the encapsulation of two different drugs, which are invariably different in structure and in their solubility in water. We have characterized these dual drug vehicular capsules by confocal laser scanning microscopy, atomic force microscopy, visible microscopy, and transmission electron microscopy. The growth of a thin film on a flat substrate by LbL was monitored by UV-vis spectra. The desorption kinetics of two drugs from the thin film was modeled by a second-order rate model.
将疏水性和亲水性药物整合到聚合物微胶囊中，为开发一种结合这两类不同材料最佳特性的新型药物递送系统提供了可能性。最近，我们报道了一种不带电荷的水不溶性药物被包裹在聚合物膜中。疏水性药物采用层层（LbL）技术沉积，该技术基于带相反电荷的聚电解质在带电基底上的顺序吸附。在本文中，我们报道了两种不同药物的包裹情况，这两种药物在结构和在水中的溶解度方面必然存在差异。我们通过共聚焦激光扫描显微镜、原子力显微镜、光学显微镜和透射电子显微镜对这些双药载体胶囊进行了表征。通过紫外可见光谱监测了LbL在平坦基底上薄膜的生长情况。用二级速率模型对两种药物从薄膜中的解吸动力学进行了建模。
