Klamer Keva, Craig Joshua, Haines Christina, Sullivan KiAnna, Seres Peter, Ekstrand Chelsea
Ekstrand Neuroimaging Lab, Department of Neuroscience, University of Lethbridge, 4401 University Dr W, Lethbridge, AB, T1K 3M4, Canada.
Peter S. Allen MRI Research Centre, University of Alberta, 116 St & 85 Ave, Edmonton, AB, T6G 2R3, Canada.
J Headache Pain. 2025 Mar 28;26(1):62. doi: 10.1186/s10194-025-01993-6.
Migraine is a common neurological disorder that impacts approximately 12% of the general population and is characterized by moderate to severe headaches, nausea, mood changes, and fatigue. It impacts lower-level visual and auditory processing, causing hypersensitivities that lead to heightened audiovisual multisensory integration. However, the impact of migraine on the processing of complex, audiovisual stimuli is still unclear. Additionally, migraine may induce hypersensitivities to emotional arousal and valence, though the relative significance of these factors remains unknown. The current study seeks to identify how migraine impacts synchronous neural processing of complex, audiovisual stimuli, and how this differs based on the emotional arousal and valence of the stimulus. To do so, we collected functional magnetic resonance imaging data (fMRI) from 22 migraineurs and 21 healthy controls during the passive viewing of three audiovisual films of differing emotional arousal and valence. We identified that, in response to a negative valence, high arousal emotional stimulus, the migraine group showed greater neural synchrony in regions associated with multisensory integration, including the bilateral posterior superior temporal gyrus (pSTG), superior parietal lobule (SPL), and left middle temporal gyrus (MTG). There were no significant differences in neural synchrony between the migraine and control groups in response to positive valence, high arousal and neutral valence, low arousal stimuli. These findings suggest that migraine involves hypersensitivity to audiovisual movies as a function of negative emotional valence, where negative/aversive emotional states may drive greater synchrony in multisensory integration. Overall, this research highlights distinct pathways through which emotion and arousal impact neural processing in migraine.
偏头痛是一种常见的神经系统疾病，影响着约12%的普通人群，其特征为中度至重度头痛、恶心、情绪变化和疲劳。它会影响较低层次的视觉和听觉处理，导致超敏反应，进而增强视听多感官整合。然而，偏头痛对复杂视听刺激处理的影响仍不清楚。此外，偏头痛可能会引发对情绪唤醒和效价的超敏反应，尽管这些因素的相对重要性尚不清楚。本研究旨在确定偏头痛如何影响复杂视听刺激的同步神经处理，以及这如何因刺激的情绪唤醒和效价而有所不同。为此，我们在22名偏头痛患者和21名健康对照者被动观看三部具有不同情绪唤醒和效价的视听影片时，收集了功能磁共振成像数据（fMRI）。我们发现，在面对负性效价、高唤醒情绪刺激时，偏头痛组在与多感官整合相关的区域，包括双侧后颞上回（pSTG）、顶上小叶（SPL）和左颞中回（MTG），表现出更大的神经同步性。在面对正性效价、高唤醒刺激和中性效价、低唤醒刺激时，偏头痛组和对照组在神经同步性上没有显著差异。这些发现表明，偏头痛涉及对视听电影的超敏反应，这是负性情绪效价的一种功能，其中负性/厌恶情绪状态可能会在多感官整合中驱动更大的同步性。总体而言，本研究突出了情绪和唤醒影响偏头痛神经处理的不同途径。
