Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Eur J Neurosci. 2021 Mar;53(6):1988-1997. doi: 10.1111/ejn.15078. Epub 2020 Dec 30.
Phonophobia in migraineurs may be due to lower hearing threshold (HT) and higher brainstem neuronal excitability. We report the correlation of phonophobia in migraineurs with HT, brain stem auditory evoked potential (BAEP) findings, and auditory triggers. Sixty-one migraineurs and 101 controls were included for HT, of whom 59 migraineurs and 31 controls had BAEP studies. Clinical details, migraine triggers, and headache frequency were noted. Hearing threshold was measured, and amplitudes of waves I to V of BAEP studies were measured. Migraineurs had lower HT compared with controls (41.61 ± 5.25 versus 45.39 ± 6.26 dB; p < 0.001) especially in chronic migraine (40.24 ± 4.81; p < 0.001). Hearing threshold correlated with headache frequency (p < 0.05) and auditory, visual, and tactile (p < 0.05) triggers. Hearing threshold was lower during headache (p < 0.001). Wave II, III, and IV amplitudes of BAEP were higher in migraineurs than the controls. Wave II (p < 0.05) and III (p < 0.05) amplitudes correlated with HT. Migraineurs have lower HT, especially in those having chronic migraine, ictal HT recording, and multiple sensory triggers. Higher amplitudes of BAEP waves in migraineurs and their relationship with the frequency of headache and HT suggest the sensitization of brainstem auditory neurons.
偏头痛患者的恐声症可能是由于听力阈值 (HT) 降低和脑干神经元兴奋性升高所致。我们报告了偏头痛患者的恐声症与 HT、脑干听觉诱发电位 (BAEP) 结果和听觉触发因素的相关性。纳入了 61 名偏头痛患者和 101 名对照者进行 HT 检查，其中 59 名偏头痛患者和 31 名对照者进行了 BAEP 研究。记录了临床细节、偏头痛触发因素和头痛频率。测量了听力阈值，并测量了 BAEP 研究中波 I 至 V 的振幅。偏头痛患者的 HT 明显低于对照组（41.61 ± 5.25 与 45.39 ± 6.26 dB；p < 0.001），尤其是慢性偏头痛患者（40.24 ± 4.81；p < 0.001）。听力阈值与头痛频率（p < 0.05）以及听觉、视觉和触觉触发因素（p < 0.05）相关。头痛期间的 HT 明显更低（p < 0.001）。BAEP 的波 II、III 和 IV 振幅在偏头痛患者中高于对照组。波 II（p < 0.05）和 III（p < 0.05）振幅与 HT 相关。偏头痛患者的 HT 较低，尤其是那些患有慢性偏头痛、发作性 HT 记录和多种感觉触发因素的患者。偏头痛患者的 BAEP 波振幅较高及其与头痛频率和 HT 的关系表明脑干听觉神经元的敏化。
