Fedoseeva O V, Kalyuzhnyi L V, Sudakov K V
P.K. Anokhin Institute of Normal Physiology, USSR Academy of Medical Sciences, Moscow.
Acupunct Electrother Res. 1990;15(1):1-8. doi: 10.3727/036012990816358306.
In rabbits, auriculo-acupuncture electrostimulation with frequencies of 15 and 100 Hz induced an analgesic effect expressed by a decrease in the amplitude of a cortical somatosensory evoked potential in response to tooth pulp electrostimulation. Intracerebroventricular saralasin injection abolished or blocked the effect of auriculo-acupuncture stimulation at 100 Hz, but not at 15 Hz frequency. Intravenous injection of naloxone abolished the effect of auriculo-acupuncture stimulation at 15 Hz but not at 100 Hz frequency. Methysergide or D,L-p-chlorophenylalanine injection diminished but did not entirely block the effect of auriculo-acupuncture stimulation at 100 Hz. This suggests that the neuropeptide angiotensin II is a antinociceptive factor in dental peptide analgesic mechanisms induced by auriculo-acupuncture stimulation at 100 Hz frequency.
在兔子身上，频率为15赫兹和100赫兹的耳针电刺激产生了镇痛效果，表现为对牙髓电刺激的皮质体感诱发电位幅度降低。脑室内注射沙拉新可消除或阻断100赫兹频率的耳针刺激效果，但对15赫兹频率无效。静脉注射纳洛酮可消除15赫兹频率的耳针刺激效果，但对100赫兹频率无效。注射麦角新碱或D，L-对氯苯丙氨酸可减弱但不能完全阻断100赫兹频率的耳针刺激效果。这表明神经肽血管紧张素II是100赫兹频率耳针刺激诱导的牙科肽镇痛机制中的一种抗伤害感受因子。
