Giraldo Montoya Isabel, Rodríguez Gázquez María de Los Angeles, Mejía Cadavid Luz Aída, Quirós Jaramillo Alexandra
Facultad de Enfermería, Universidad Pontificia Bolivariana, Medellín, Colombia.
Enferm Clin. 2009 Sep-Oct;19(5):267-74. doi: 10.1016/j.enfcli.2009.05.004. Epub 2009 Sep 6.
To evaluate the effectiveness of sucrose use in the prevention of pain during venipuncture in neonates.
Double blind randomized control trial. The population consisted of hospitalized neonates subjected to venipuncture. Sample size was calculated with a 95% confidence level, 80% power, minimum proportion of neonates with pain 40% in the study group and 70% in the control group. The minimum sample size was 49 newborns per group. Five minutes before venipuncture, the neonates received 1cc of oral solution of 12% sucrose (study group) or distilled water (control group). During the procedure the pain level was evaluated with NIPS (Neonatal Infant Pain Scale). A data base was created, and the information processed and analysed using the SPSS program.
A total of 111 neonates were analysed, (55 in study group and 56 in control group). Bivariate analysis showed a smaller NIPS score in the group that received sucrose. Linear regression model explained that the significant variables for pain during the procedure were: hours since birth and the absence of non-nutritious suction, not being related to the sucrose administration.
Neonates that received the oral solution of sucrose before venipuncture had an average pain score lower than the placebo controlled group.
评估使用蔗糖预防新生儿静脉穿刺时疼痛的有效性。
双盲随机对照试验。研究对象为接受静脉穿刺的住院新生儿。样本量按95%置信水平、80%检验效能计算，研究组新生儿疼痛的最小比例为40%，对照组为70%。每组最小样本量为49例新生儿。在静脉穿刺前5分钟，新生儿口服1毫升12%蔗糖溶液（研究组）或蒸馏水（对照组）。在操作过程中，使用新生儿婴儿疼痛量表（NIPS）评估疼痛程度。建立数据库，并使用SPSS程序对信息进行处理和分析。
共分析了111例新生儿（研究组55例，对照组56例）。双变量分析显示，接受蔗糖的组NIPS评分较低。线性回归模型表明，操作过程中疼痛的显著变量为：出生后的小时数和无非营养性吸吮，与蔗糖给药无关。
在静脉穿刺前接受蔗糖溶液的新生儿平均疼痛评分低于安慰剂对照组。
