Kobayashi K, Atoh M, Konoeda Y, Yagita A, Inoko H, Sekiguchi S
Department of Laboratory Medicine, National Defense Medical College, Saitama, Japan.
Clin Exp Immunol. 1990 Jun;80(3):400-3. doi: 10.1111/j.1365-2249.1990.tb03300.x.
We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (n = 17) but completely absent in the controls (n = 35) (chi2 = 47.6, P less than 0.001). The frequency of HLA-DR2 antigen was significantly higher in UC patients (85% versus 28% in controls, P less than 0.001). Furthermore, HLA-DQw1 antigen was also increased in UC patients (96% versus 60% in controls, P less than 0.001). However, HLA-DR4 antigen was significantly decreased in UC patients (12% versus 37%, P = 0.02). HLA-DR1 antigen was not found in UC patients and was present in only 15% of the controls. These results suggest that TcR beta chain and HLA-DQw1 antigen may be important in the pathogenesis of Japanese UC.
我们研究了 HLA 分型的日本溃疡性结肠炎（UC）患者的 T 细胞抗原受体（TcR）恒定β链基因。所有日本 UC 患者（n = 17）均存在 TcR 恒定β EcoRI 6.0-kb 片段，但对照组（n = 35）中完全不存在（χ2 = 47.6，P < 0.001）。UC 患者中 HLA-DR2 抗原的频率显著更高（85% 对比对照组的 28%，P < 0.001）。此外，UC 患者中 HLA-DQw1 抗原也有所增加（96% 对比对照组的 60%，P < 0.001）。然而，UC 患者中 HLA-DR4 抗原显著减少（12% 对比 37%，P = 0.02）。UC 患者中未发现 HLA-DR1 抗原，仅 15% 的对照组中有该抗原。这些结果表明，TcR β链和 HLA-DQw1 抗原可能在日本 UC 的发病机制中起重要作用。
