Kress Elsa, Samarut Jacques, Plateroti Michelina
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, INRA, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France.
Mol Cell Endocrinol. 2009 Dec 10;313(1-2):36-49. doi: 10.1016/j.mce.2009.08.028. Epub 2009 Sep 6.
Amphibian metamorphosis perfectly illustrates a key paradox: thyroid hormones control diverse cellular processes depending on the tissue context. This point is also reinforced by a recent accumulation of evidence. For example, thyroid hormones and their nuclear receptor TRs have been described to function in different systems in synergy and/or in antagonism with other signaling pathways. This interaction helps explain their pleiotropic roles. This review summarizes the most important advances in this field, focusing in particular on the key action of thyroid hormones in controlling the balance between the processes of cell proliferation and cell differentiation in a few organs, with special attention paid to the intestine. We highlight similarities between the cellular and molecular events occurring during postnatal intestinal maturation at metamorphosis in amphibians, and comparable events observed at weaning in mice.
甲状腺激素根据组织环境控制多种细胞过程。最近积累的证据也强化了这一点。例如，甲状腺激素及其核受体TR已被描述为在不同系统中与其他信号通路协同和/或拮抗发挥作用。这种相互作用有助于解释它们的多效性作用。本综述总结了该领域最重要的进展，特别关注甲状腺激素在控制一些器官中细胞增殖和细胞分化过程平衡方面的关键作用，尤其关注肠道。我们强调了两栖动物变态时出生后肠道成熟过程中发生的细胞和分子事件，与小鼠断奶时观察到的类似事件之间的相似性。
