Xiang Guang-da, Pu Jinhui, Sun Huiling, Zhao Linshuang, Yue Ling, Hou Jie
Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuluo Road 627, Wuhan 430070, Hubei Province, People's Republic of China.
Eur J Endocrinol. 2009 Nov;161(5):755-61. doi: 10.1530/EJE-09-0395. Epub 2009 Sep 8.
Impairment of flow-mediated endothelium-dependent arterial dilation (FMD) exists in patients with subclinical hypothyroidism (sHT). Several studies showed that exercise training can improve FMD in patients with type 1 and type 2 diabetes. Therefore, we hypothesized that exercise training can also improve FMD in subjects with sHT. The purpose of the study was to test this hypothesis.
We selected 30 sedentary women with sHT and 27 sedentary healthy women with euthyroid. All individuals participated in an exercise training of 6 months. Before and after exercise training, high resolution ultrasound was used to measure FMD.
At baseline, FMD among subjects with sHT was 3.87%, which was significantly lower than that in controls (5.98%; P<0.001). After 6 months of exercise, there was a remarkable increase in FMD (31.3%) and VO(2) max (36.7%; P<0.01), and significant decreases in total cholesterol (20%), low-density lipoprotein cholesterol (LDL; 29%), triglycerides (TG; 47.6%), and C-reactive protein (CRP; 61.5%; P<0.05) were observed over the exercise in patients with sHT. The absolute changes in FMD showed significant correlation with changes in LDL (r=-0.596), TG (r=-0.532), and CRP (r=-0.511; P<0.01), and multiple regression analysis showed changes of LDL, TG, CRP were significant determinants of changes of FMD in sHT patients during exercise course.
Regular aerobic exercise improves FMD in sHT patients, and changes of lipids and inflammation during the exercise period may partially contribute to the improvement of endothelial function.
亚临床甲状腺功能减退症（sHT）患者存在血流介导的内皮依赖性动脉扩张（FMD）受损情况。多项研究表明，运动训练可改善1型和2型糖尿病患者的FMD。因此，我们推测运动训练也可改善sHT患者的FMD。本研究的目的是验证这一假设。
我们选取了30名久坐不动的sHT女性和27名久坐不动的甲状腺功能正常的健康女性。所有个体均参加了为期6个月的运动训练。运动训练前后，使用高分辨率超声测量FMD。
基线时，sHT患者的FMD为3.87%，显著低于对照组（5.98%；P<0.001）。运动6个月后，sHT患者的FMD显著增加（31.3%），最大摄氧量（VO₂max）增加（36.7%；P<0.01），总胆固醇（20%）、低密度脂蛋白胆固醇（LDL；29%）、甘油三酯（TG；47.6%）和C反应蛋白（CRP；61.5%）显著降低（P<0.05）。FMD的绝对变化与LDL（r=-0.596）、TG（r=-0.532）和CRP（r=-0.511；P<0.01）的变化显著相关，多元回归分析表明，LDL、TG、CRP的变化是sHT患者运动过程中FMD变化的重要决定因素。
规律的有氧运动可改善sHT患者的FMD，运动期间血脂和炎症的变化可能部分有助于内皮功能的改善。
