Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Dev Dyn. 2012 Jan;241(1):85-91. doi: 10.1002/dvdy.22759. Epub 2011 Oct 3.
Renewing tissues in the adult organism such as the gastrointestinal (GI) epithelium depend on stem cells for epithelial maintenance and repair. Yet, little is known about the developmental origins of adult stem cells and their niches. Studies of Drosophila adult midgut precursors (AMPs), a population of endodermal progenitors, demonstrate that adult intestinal stem cells (ISCs) arise from the AMP lineage and provide insight into the stepwise process by which the adult midgut epithelium is established during development. Here, I review the current literature on AMPs, where local, inductive and long-range humoral signals have been found to control progenitor cell behavior. Future studies will be necessary to determine the precise mechanism by which adult intestinal stem cells are established in the endodermal lineage.
在成年生物体中，如胃肠道（GI）上皮组织等组织的更新依赖于干细胞来维持和修复上皮组织。然而，人们对成年干细胞及其生态位的发育起源知之甚少。对果蝇成年肠道前体细胞（AMPs）的研究，这是一群内胚层祖细胞，表明成年肠道干细胞（ISCs）起源于 AMP 谱系，并深入了解了成年肠道上皮组织在发育过程中逐步建立的过程。在这里，我回顾了关于 AMPs 的现有文献，其中发现局部、诱导和长距离体液信号控制祖细胞的行为。未来的研究将有必要确定内胚层谱系中成年肠道干细胞的确切建立机制。
