Witkowicz Joanna
Katedra i Klinika Nefrologii, Endokrynologii i Chorób Przemiany Materii, Slaskiego Uniwersytetu Medycznego w Katowicach.
Przegl Lek. 2009;66(5):253-6.
Aristolochic acid nephropathy is a chronic, fibrosing, interstitial nephritis caused by aristolochic acid (AA), which is a component of the plants of Aristolochiacae family. It was first reported in 1993, in Belgium as a Chinese herb nephropathy, in patients who received a slimming regimen containing AA. The term aristolochic acid nephropathy also includes Balcan endemic nephropathy and other endemic tubulointerstitial fibrosis. Moreover, AA is a human carcinogen which induces urothelial cancer. The AA-containing herbs are banned in many countries and FDA published the warnings concerning the safety of AA-containing botanical remedies in 2000. Regarding the increasing interest in herbal medicines, uncontrolled access to botanical remedies and replacement of one herb by another AA-containing compounds makes thousands of people all around the world at risk of this grave disease.
马兜铃酸肾病是一种由马兜铃酸（AA）引起的慢性、纤维化间质性肾炎，马兜铃酸是马兜铃科植物的一种成分。1993年，它首次在比利时被报道为一种中草药肾病，发生在服用含马兜铃酸减肥疗法的患者身上。马兜铃酸肾病这一术语还包括巴尔干地方性肾病和其他地方性肾小管间质性纤维化。此外，马兜铃酸是一种能诱发尿路上皮癌的人类致癌物。许多国家已禁止使用含马兜铃酸的草药，美国食品药品监督管理局（FDA）在2000年发布了关于含马兜铃酸植物药安全性的警告。鉴于人们对草药的兴趣日益浓厚，对植物药的无节制获取以及用含马兜铃酸的化合物替代另一种草药，使得全世界成千上万的人面临患这种严重疾病的风险。
