Sekita S, Kamakura H, Yasuda I, Hamano T, Satake M
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1998(116):195-6.
Aristolochic acids are nitrophenanthrenes with a carboxylic acid fanction which have been found only among the Aristolochiaceae. In 1993, rapidly progressive interstitial renal fibrosis has been reported in women have been on a slimming regimen including Chinese herbal medicines in Belgium. In Japan, at the Kansai district, several cases of Chinese herbs nephropathy have been reported quite recently. In both cases, aristolochic acids was detected in the Chinese herbal medicines taken by the patients. We have Asiasarum Root, a species of Aristolochiaceae, in Japanese Pharmacopoeia. Therefore, we quantitatively analysed aristolochic acids in these herbal medicines and related plants.
马兜铃酸是一类带有羧酸官能团的硝基菲，仅在马兜铃科植物中发现。1993年，有报道称在比利时，服用含中草药的减肥疗法的女性中出现了快速进展性间质性肾纤维化。在日本关西地区，最近也报道了几例中草药肾病病例。在这两个案例中，均在患者服用的中草药中检测到了马兜铃酸。日本药局方收载了马兜铃科植物细辛。因此，我们对这些草药及相关植物中的马兜铃酸进行了定量分析。
