The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Road, Beijing 100083, China.
Org Lett. 2009 Sep 17;11(18):4136-8. doi: 10.1021/ol901608k.
A new and efficient samarium diiodide-promoted carbon-carbon bond fragmentation reaction of alpha-aminomethyl malonates, taking place normally at room temperature and generating the corresponding deaminomethylation products in 74-94% yields, is reported. The presence of the amino group is necessary for the success of the current transformation.
报告了一种新的、高效的钐二碘化物促进的α-氨甲基丙二酸酯的碳-碳键断裂反应，该反应通常在室温下进行，以 74%-94%的收率生成相应的去氨甲基化产物。氨基的存在对于当前转化的成功是必要的。
