Stevenson J C, Cust M P, Gangar K F, Hillard T C, Lees B, Whitehead M I
Wynn Institute for Metabolic Research, London, UK.
Lancet. 1990 Aug 4;336(8710):265-9. doi: 10.1016/0140-6736(90)91801-g.
66 early postmenopausal women were randomised to 28-day cycles of either transdermal hormone replacement therapy--continuous oestradiol 17-beta 0.05 mg daily, with norethisterone acetate 0.25 mg daily for 14 of each 28 days--or oral therapy--continuous conjugated equine oestrogens 0.625 mg daily, with dl-norgestrel 0.15 mg daily for 12 of each 28 days. An untreated reference group of 30 women were studied concurrently. Bone density was measured in the lumbar spine and proximal femur by dual photon absorptiometry at 6-month intervals for 18 months. Skeletal turnover was assessed by serum measurements of calcium, phosphate, and alkaline phosphatase, and by urine estimations of hydroxyproline/creatinine and calcium/creatinine excretion. In both treatment groups by comparison with the untreated groups by comparison with the untreated group, bone density increased in the vertebrae and proximal femur and biochemical measurements indicated a significant reduction in bone turnover.
66名绝经早期女性被随机分为两组，分别接受为期28天的经皮激素替代疗法或口服疗法。经皮激素替代疗法为每日持续使用17-β雌二醇0.05毫克，每28天中有14天每日加用醋酸炔诺酮0.25毫克；口服疗法为每日持续使用结合马雌激素0.625毫克，每28天中有12天每日加用左炔诺孕酮0.15毫克。同时对30名未接受治疗的女性组成的参照组进行研究。每隔6个月采用双能光子吸收法测量腰椎和股骨近端的骨密度，为期18个月。通过检测血清钙、磷和碱性磷酸酶，以及估算尿羟脯氨酸/肌酐和钙/肌酐排泄量来评估骨转换。与未治疗组相比，两个治疗组的椎骨和股骨近端骨密度均增加，生化检测表明骨转换显著降低。
