1985 年至 2005 年成人囊性纤维化患者呼吸道定植病原体的趋势。
Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985-2005.
机构信息
Adult Cystic Fibrosis Dept, NHLI/Imperial College and Royal Brompton Hospital, London, United Kingdom.
出版信息
J Cyst Fibros. 2009 Dec;8(6):386-91. doi: 10.1016/j.jcf.2009.08.003. Epub 2009 Sep 8.
INTRODUCTION
The treatment of patients with CF has continued to evolve. We hypothesised that sputum microbiology may have changed as a result of this.
METHOD
Retrospective analysis of sputum microbiology from adult CF patients (1985 to 2005) using the Royal Brompton Hospital CF database.
RESULTS
Colonisation with Pseudomonas aeruginosa or Staphylococcus aureus between 1985 and 2005 remained stable (77 to 82%, p=0.159; 54 to 47%, p=0.108; respectively). Haemophilus influenzae (48 to 6%; p<0.001), Aspergillus species (18 to 9%; p=0.002) and Burkholderia cepacia complex (9 to 4%; p=0.041) prevalence decreased. Stenotrophomonas maltophilia and MRSA increased (1 to 4%, p=0.02; 1 to 6%, p=0.002, respectively).
CONCLUSION
P. aeruginosa colonisation has remained stable; there has been a decline in B. cepacia complex, H. influenzae and Aspergillus sp., and only a small increase in S. maltophilia and MRSA. Intensive antibiotic strategies have been employed, which, so far, have not resulted in clinically significant emergence of new pathogens.
简介
囊性纤维化（CF）患者的治疗方法不断发展。我们假设，这可能导致痰液微生物群发生了变化。
方法
使用皇家布朗普顿医院 CF 数据库对 1985 年至 2005 年成人 CF 患者的痰液微生物群进行回顾性分析。
结果
1985 年至 2005 年间，铜绿假单胞菌或金黄色葡萄球菌的定植率保持稳定（分别为 77%至 82%，p=0.159；54%至 47%，p=0.108）。流感嗜血杆菌（48%至 6%，p<0.001）、曲霉菌属（18%至 9%，p=0.002）和洋葱伯克霍尔德菌复合群（9%至 4%，p=0.041）的流行率下降。嗜麦芽窄食单胞菌和耐甲氧西林金黄色葡萄球菌（MRSA）的增加（1%至 4%，p=0.02；1%至 6%，p=0.002）。
结论
铜绿假单胞菌的定植率保持稳定；洋葱伯克霍尔德菌复合群、流感嗜血杆菌和曲霉菌属的数量减少，仅嗜麦芽窄食单胞菌和 MRSA 略有增加。目前已采用强化抗生素策略，但尚未导致临床上出现新的重要病原体。
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