Sannita W G, Irwin P, Fink M
Neuropsychobiology. 1976;2(5-6):283-90. doi: 10.1159/000117558.
Effects of the heptapeptide ACTH4-10 (Org OI-63) on EEG, some memory tests, and behavior were examined in 12 normal male volunteers under 30 years of age. An intravenous dose of 60 mg was compared to placebo in a Latin square design. EEG was recorded for 2 h after administration of ACTH4-10 or placebo and was quantified by power spectral density analysis. Drug differences were tested by analyses of variance and covariance. No statistical drug effect was seen on the EEG or behavioral measures. Of the psychological tests, only the digit span test showed a decrease in number of errors with ACTH4-10 (p less than or equal to o.05). These results are consistent with previous studies and suggest that an intravenous bolus of ACTH4-10 has a limited effect on the brain function tested.
在12名30岁以下的正常男性志愿者中，研究了七肽促肾上腺皮质激素4 - 10（Org OI - 63）对脑电图（EEG）、一些记忆测试和行为的影响。采用拉丁方设计，将静脉注射60毫克的剂量与安慰剂进行比较。在注射促肾上腺皮质激素4 - 10或安慰剂后记录2小时的脑电图，并通过功率谱密度分析进行量化。通过方差分析和协方差分析来检验药物差异。在脑电图或行为测量中未观察到统计学上的药物效应。在心理测试中，只有数字广度测试显示促肾上腺皮质激素4 - 10使错误数量减少（p小于或等于0.05）。这些结果与先前的研究一致，表明静脉推注促肾上腺皮质激素4 - 10对所测试的脑功能影响有限。
