Department of Neuropsychology and Psychopharmacology, Facultyof Psychology and Neuroscience, Maastricht University, The Netherlands.
J Clin Psychopharmacol. 2009 Oct;29(5):439-43. doi: 10.1097/JCP.0b013e3181b3b5f3.
Although antihistamines are known for their sedative adverse effects, fexofenadine was previously shown to have stimulating effects. These stimulant effects were rather mild in magnitude and were only demonstrated in tasks with a high workload.
The present study was set up to compare the magnitude of the stimulant effect of fexofenadine with those of 2 psychostimulants, modafinil and methylphenidate.
Sixteen healthy volunteers (5 males and 11 females; mean age, 21.8 years) participated in a 4-way, placebo-controlled, crossover study. The effects of fexofenadine (360 mg), modafinil (200 mg), methylphenidate (20 mg), and placebo were compared in a critical tracking, divided attention, motor impulsivity, and vigilance task.
In this study, no significant stimulant effects of fexofenadine were found in any of the tasks. Modafinil only improved reaction time in the vigilance task, whereas methylphenidate improved performance in the divided attention and vigilance tasks. In addition, performance after methylphenidate treatment was also better than after fexofenadine in the divided attention and vigilance tasks.
From the results, it can be concluded that the stimulating effects of methylphenidate are confirmed, whereas the stimulating effects of fexofenadine were not demonstrated in this study. It is evident that the stimulating effects of fexofenadine, which were apparent in previous studies, are not of the same magnitude as the effects of known psychostimulants such as methylphenidate.
尽管抗组胺药以其镇静的副作用而闻名，但先前已证明非索非那定具有刺激作用。这些刺激作用的强度相当温和，仅在高工作量的任务中表现出来。
本研究旨在比较非索非那定的刺激作用强度与两种精神兴奋剂莫达非尼和哌甲酯的刺激作用强度。
16 名健康志愿者（5 名男性和 11 名女性；平均年龄 21.8 岁）参加了一项 4 向、安慰剂对照、交叉研究。在一项关键跟踪、分散注意力、运动冲动和警觉任务中，比较了非索非那定（360mg）、莫达非尼（200mg）、哌甲酯（20mg）和安慰剂的作用。
在这项研究中，在任何一项任务中，非索非那定都没有明显的刺激作用。莫达非尼仅改善了警觉任务中的反应时间，而哌甲酯改善了分散注意力和警觉任务的表现。此外，哌甲酯治疗后的表现也优于分散注意力和警觉任务中的非索非那定。
从结果可以得出结论，哌甲酯的刺激作用得到了证实，而在本研究中，非索非那定的刺激作用并未得到证实。显然，非索非那定在先前研究中表现出的刺激作用的强度与已知的精神兴奋剂如哌甲酯的作用强度不同。
