Liu Yia-Ping, Tung Che-Se, Lin Yu-Lung, Chuang Chia-Hsin
Department of Physiology and Biophysics, National Defense Medical Center, Min-Chuan East Road, Taipei 114, Taiwan, Republic of China.
Psychopharmacology (Berl). 2011 Jan;213(1):155-66. doi: 10.1007/s00213-010-2019-0. Epub 2010 Sep 24.
Individuals who experience sleep loss may exhibit certain physiological abnormalities. Central stimulant drugs have been studied in sleep-loss conditions, and some of them might be therapeutically beneficial. Modafinil (diphenyl-methyl-sulfinyl-2-acetamide, MOD) has been increasingly employed for elevating alertness and vigilance in recent years, yet the underlying mechanism of actions for MOD is not fully understood.
To examine the behavioral effect of MOD following rapid eye movement sleep deprivation (REMD) in rats. A five-choice serial reaction time task (5-CSRTT) was employed to investigate animals' attentional performance and impulsive reactivity.
Rats of different ages were trained to learn the 5-CSRTT. REMD with the water platform method was applied for 96 h. The impacts of REMD on 5-CSRTT in middle-age (32-weeks-old) and young-adult (12-week-old) rats were compared with baseline or a condition with shorter visual stimulus duration.
The results revealed that following REMD, young-adult but not middle-age rats were liable to be affected in their performances of the 5-CSRTT. In young-adult rats, while MOD had no contributions to the effect of REMD, it worsened rats' performance following REMD when the stimulus duration was shortened, as shown by the reduced number of correct responses and prolonged magazine latency.
These results suggest that aging might be a crucial factor for the physiological impact following REMD. MOD should be used cautiously, particularly, in conditions that require REM sleep.
经历睡眠缺失的个体可能会表现出某些生理异常。中枢兴奋剂药物已在睡眠缺失的情况下进行了研究，其中一些可能具有治疗益处。莫达非尼（二苯基 - 甲基 - 亚磺酰基 - 2 - 乙酰胺，MOD）近年来越来越多地用于提高警觉性和警惕性，但其作用的潜在机制尚未完全了解。
研究莫达非尼在大鼠快速眼动睡眠剥夺（REMD）后的行为效应。采用五选择连续反应时间任务（5 - CSRTT）来研究动物的注意力表现和冲动反应性。
对不同年龄的大鼠进行训练以学习5 - CSRTT。采用水平台法进行96小时的REMD。将REMD对中年（32周龄）和年轻成年（12周龄）大鼠5 - CSRTT的影响与基线或视觉刺激持续时间较短的情况进行比较。
结果显示，REMD后，年轻成年大鼠而非中年大鼠在5 - CSRTT的表现上容易受到影响。在年轻成年大鼠中，虽然莫达非尼对REMD的影响没有作用，但当刺激持续时间缩短时，它会使REMD后大鼠的表现恶化，表现为正确反应次数减少和杂志延迟延长。
这些结果表明，衰老可能是REMD后生理影响的关键因素。应谨慎使用莫达非尼，特别是在需要快速眼动睡眠的情况下。
