Mukai Akira, Fukai Toshio, Hoshino Yasutaka, Yazawa Katsukiyo, Harada Ken-ichi, Mikami Yuzuru
Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba, Japan.
J Antibiot (Tokyo). 2009 Nov;62(11):613-9. doi: 10.1038/ja.2009.90. Epub 2009 Sep 11.
Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows a strong activity against acid-fast bacilli such as the Mycobacterium and Gordonia species. Nocardithiocin was highly active against rifampicin-resistant as well as -sensitive Mycobacterium tuberculosis strains, and most of the resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 microg ml(-1). The structure of the thiopeptide antibiotic containing thiazole, natural and unnatural amino acids was elucidated by MS and NMR spectral analyses.
诺卡硫霉素是由致病性巴西诺卡氏菌菌株IFM 0757产生的一种新型硫肽化合物。它对诸如分枝杆菌属和戈登氏菌属等抗酸杆菌具有很强的活性。诺卡硫霉素对耐利福平以及对利福平敏感的结核分枝杆菌菌株均具有高活性，并且大多数耐药菌株在浓度范围为0.025至1.56微克/毫升时受到抑制。通过质谱和核磁共振光谱分析阐明了含有噻唑、天然和非天然氨基酸的硫肽抗生素的结构。
